Cancer Genet Cytogenet. 1990 Nov 1;50(1):9-14.

Trisomy 7 may be a primary change in noninvasive transitional cell carcinoma of the bladder.

Berrozpe G, Miró R, Caballin MR, Salvador J, Egozcue J.

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Institut de Biologia Fonamental Vincent Villar Palasí, Universitat Autònoma de Barcelona, Spain.

Abstract

We describe two cases of transitional cell carcinoma of the bladder associated with trisomy 7. In one of them, trisomy 7 was the only chromosome abnormality observed. In the second case, trisomy 7 was found in 25 (80.6%) of the metaphases; in two of them this was the only anomaly, while in three metaphases trisomy 8 was also present, and in other two trisomy 10 was also observed. Our results suggest that trisomy 7 could be a primary change in TCC, and a review of the literature indicates that when it is present as the sole karyotypic abnormality is may be associated with a non-invasive behavior of the tumor.

PMID:: 2253193; [PubMed - indexed for MEDLINE]

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