Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction

Ann Plast Surg. 2012 May;68(5):432-4. doi: 10.1097/SAP.0b013e31823b6ac6.

Abstract

Background: The use of acellular dermal matrix (ADM) has become a routine practice in implant-based breast reconstruction. Bilateral mastectomy is becoming more popular in cases of unilateral breast cancer. ADM has been associated with an increased incidence of complications.

Methods: We identified cases of bilateral implant-based breast reconstruction over a 5-year period. Data collection included medical comorbities, details of operative management, and details of postoperative cancer treatment.

Results: On univariate analysis, the use of ADM (31% vs. 7%, P = 0.018), smoking (37% vs. 13%, P = 0.045), and open wound (55% vs. 13%, P = 0.006) were significantly associated with increased risk of infection. Multivariate analysis revealed open wound as the strongest predictor of infection.

Conclusions: The use of ADM is associated with an increased risk of infection in bilateral implant-based breast reconstruction. However, it does not appear to be an independent risk factor by itself.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / adverse effects*
  • Breast Implantation / instrumentation*
  • Dermis
  • Female
  • Humans
  • Logistic Models
  • Middle Aged
  • Multivariate Analysis
  • Retrospective Studies
  • Risk Factors
  • Surgical Wound Infection / epidemiology
  • Surgical Wound Infection / etiology*

Substances

  • Biocompatible Materials