Display Settings:

Format

Send to:

Choose Destination
Nat Commun. 2012 Apr 24;3:796. doi: 10.1038/ncomms1796.

Bats host major mammalian paramyxoviruses.

Author information

  • 1Institute of Virology, University of Bonn Medical Centre, Bonn 53127, Germany.

Erratum in

  • Nat Commun. 2014;5:3032. Cottontail, Veronika M [added]; Knörnschild, Mirjam [added].

Abstract

The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.

PMID:
22531181
[PubMed - indexed for MEDLINE]
PMCID:
PMC3343228
Free PMC Article

Images from this publication.See all images (8)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8

Publication Types, MeSH Terms, Secondary Source ID

Publication Types

MeSH Terms

Secondary Source ID

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk