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Mult Scler Int. 2012;2012:862169. doi: 10.1155/2012/862169. Epub 2012 Mar 12.

Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?

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  • 1Department of Neurology, Osaka University Graduate School of Medicine, D4, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.


Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also suspected as a prerequisite for the development of the disease. Unraveling these unresolved aspects of the disease will provide substantial insight into still controversial issues in the pathogenesis of NMO.

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