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Front Microbiol. 2012 Apr 18;3:141. doi: 10.3389/fmicb.2012.00141. eCollection 2012.

Treatment of Kaposi sarcoma-associated herpesvirus-associated cancers.

Author information

  • 1Program in Global Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

Abstract

Kaposi sarcoma (KS) is the most frequent AIDS-defining cancer worldwide. KS-associated herpesvirus (KSHV) is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular composition. They represent a challenge for cancer treatment and an opportunity to identify new mechanisms of transformation. Here, we review the current clinical insights into KSHV-associated cancers and discuss scientific insights into the pathobiology of KS, primary effusion lymphoma, and multicentric Castleman's disease.

KEYWORDS:

KSHV; lymphoma; sarcoma; therapy; viral cancer

PMID:
22529843
[PubMed]
PMCID:
PMC3328849
Free PMC Article
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