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IEEE/ACM Trans Comput Biol Bioinform. 2012 Sep-Oct;9(5):1338-51.

Time series dependent analysis of unparametrized Thomas networks.

Author information

  • 1DFG Research Center Matheon, Freie Universit√§t Berlin, Berlin, Germany. Hannes.Klarner@FU-Berlin.de

Abstract

This paper is concerned with the analysis of labeled Thomas networks using discrete time series. It focuses on refining the given edge labels and on assessing the data quality. The results are aimed at being exploitable for experimental design and include the prediction of new activatory or inhibitory effects of given interactions and yet unobserved oscillations of specific components in between specific sampling intervals. On the formal side, we generalize the concept of edge labels and introduce a discrete time series interpretation. This interpretation features two original concepts: 1) Incomplete measurements are admissible, and 2) it allows qualitative assumptions about the changes in gene expression by means of monotonicity. On the computational side, we provide a Python script, erda.py, that automates the suggested workflow by model checking and constraint satisfaction. We illustrate the workflow by investigating the yeast network IRMA.

PMID:
22529333
[PubMed - indexed for MEDLINE]
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