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Strahlenther Onkol. 2012 Jun;188(6):518-22. doi: 10.1007/s00066-012-0096-1. Epub 2012 Apr 12.

Relapsing high grade mucoepidermoid carcinoma. Long-lasting complete response following reirradiation and EGFR blockade.

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  • 1Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany. dusan.milanovic@uniklinik-freiburg.de

Abstract

BACKGROUND AND PURPOSE:

The treatment strategy for inoperable recurrent mucoepidermoid carcinoma (MEC) is not well established. Here, we present a case of a relapsed high grade MEC of the salivary glands of the hard palate that was successfully treated with a reirradiation (re-RT) and cetuximab, an antibody against epidermal growth factor receptor (EGFR).

CASE REPORT:

Twelve years after resection and adjuvant radiotherapy for high grade MEC of the salivary glands, a patient presented with inoperable recurrent disease. She received another 59.4 Gy. In addition, 400 mg/m(2) cetuximab was administered in the first week, followed by six additional weekly courses at 250 mg/m(2).

RESULTS:

Treatment was well tolerated. The patient is doing well and continuous radiological complete response (CR) is documented for 25 months after completion of the combined treatment.

CONCLUSION:

Combined re-RT and targeted inhibition of EGFR with cetuximab may be a valuable therapeutic strategy in patients with recurrent localized high grade MEC who are not candidates for radical surgery.

PMID:
22526230
[PubMed - indexed for MEDLINE]
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