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Arch Orthop Trauma Surg. 2012 Aug;132(8):1147-52. doi: 10.1007/s00402-012-1519-2. Epub 2012 Apr 24.

Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty.

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  • 1Department of Orthopaedics, University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.



Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation.


The potential role of QUIXIL(®), a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee.


Results showed that application of 2 ml QUIXIL(®) adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P = 0.026) was detected in QUIXIL(®) treated patients.


Regarding cost effectiveness and benefit no indication for the use of 2 ml QUIXIL(®) fibrin sealant in standard knee arthroplasty could be proofed statistically.

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