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Rheum Dis Clin North Am. 2012 Feb;38(1):125-39. doi: 10.1016/j.rdc.2012.03.012. Epub 2012 Apr 12.

Vitamin D and the immune system: new perspectives on an old theme.

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  • 1Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.


It is almost 30 years since an interaction between vitamin D and the immune system was first documented. Although this was initially proposed as a nonclassic effect of vitamin D associated with granulomatous diseases, our current view is now changed considerably. Recent studies have shown a potential physiologic role for vitamin D in regulating normal innate and adaptive immunity. Future studies now need to focus on the clinical implications of vitamin D–mediated immunity and, in particular, the possible beneficial effects of supplementary vitamin D with respect to infectious and autoimmune diseases.

Copyright © 2012 Elsevier Inc. All rights reserved.

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