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Rheum Dis Clin North Am. 2012 Feb;38(1):29-44. doi: 10.1016/j.rdc.2012.03.005. Epub 2012 Apr 12.

Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment.

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  • 1Department of Biochemistry and Molecular Biology, Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA.


The assessment of circulating 25(OH)D and, to a lesser degree, 1,25(OH)2D is rapidly becoming an important clinical tool in the diagnosis and management of many diverse pathologies. At present, the reference ranges for circulating 25(OH)D and 1,25(OH)2D are 32 to 100 ng/mL and 16 to 56 ng/mL, respectively, and are largely based on clinical data derived from the FDA-cleared DiaSorin assay procedures.

Copyright © 2012 Elsevier Inc. All rights reserved.

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