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Annu Rev Anal Chem (Palo Alto Calif). 2012;5:207-28. doi: 10.1146/annurev-anchem-062011-143203. Epub 2012 Apr 9.

Scanning ion conductance microscopy.

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  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.


Scanning ion conductance microscopy (SICM) is a versatile type of scanning probe microscopy for studies in molecular biology and materials science. Recent advances in feedback and probe fabrication have greatly increased the resolution, stability, and speed of imaging. Noncontact imaging and the ability to deliver materials to localized areas have made SICM especially fruitful for studies of molecular biology, and many examples of such use have been reported. In this review, we highlight new developments in the operation of SICM and describe some of the most exciting recent studies from this growing field.

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