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J Clin Invest. 2012 May;122(5):1608-11. doi: 10.1172/JCI63417. Epub 2012 Apr 23.

NADPH oxidase regulates efficacy of vaccination in aspergillosis.

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  • 1Division of Infectious Diseases, University of Cincinnati College of Medicine, and the Veterans Affairs Hospital, Cincinnati, Ohio 45267-0560, USA.


Invasive aspergillosis is often a consequence of immune suppression, and accumulating evidence points to a role for adaptive immunity. Hence, it may be possible to manipulate the adaptive immune system to enhance protective immunity in at-risk individuals. In this issue of the JCI, De Luca and colleagues describe the ontogeny of adaptive immune responses to murine aspergillosis infection in relation to vaccination. Their thought-provoking findings reveal the complexities of vaccine-induced immunity and could be used to improve vaccine efficacy.

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