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J Clin Invest. 2012 May 1;122(5):1602-5. doi: 10.1172/JCI63190. Epub 2012 Apr 23.

Epidermal Langerhans cells tune skin reactivity to contact allergens.

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  • Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1908, USA. udey@helix.nih.gov


Allergic contact dermatitis is a common disorder that has fascinated dermatologists and immunologists for decades. Extensive studies of contact sensitivity reactions in mice established a mechanistic paradigm that has been revisited in recent years, and the involvement of Langerhans cells (LCs), a population of epidermal dendritic cells, in immune responses to epicutaneously applied antigens has been questioned. In this issue of the JCI, Gomez de Agüero et al. describe an elegant series of experiments that implicate LCs in tolerance induction, positioning these cells as key regulators of immunologic barrier function.

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