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Nat Methods. 2012 Apr 22;9(7):714-6. doi: 10.1038/nmeth.1984.

An image analysis toolbox for high-throughput C. elegans assays.

Author information

  • 1Imaging Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA. carolina@broadinstitute.org

Abstract

We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.

PMID:
22522656
[PubMed - indexed for MEDLINE]
PMCID:
PMC3433711
Free PMC Article

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