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Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):131-8. doi: 10.1016/j.plefa.2012.03.009. Epub 2012 Apr 21.

Eicosanoids in skin inflammation.

Author information

  • 1School of Pharmacy and Centre for Skin Sciences, School of Life Sciences, University of Bradford, Richmond Road, Bradford BD7 1DP, UK. a.nicolaou@bradford.ac.uk

Abstract

Eicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and inflammatory and allergic disorders, including psoriasis and atopic dermatitis. This review article discusses biochemical aspects related to cutaneous eicosanoid metabolism, the contribution of these potent autacoids to skin inflammation and related conditions, and considers the importance of nutritional supplementation with bioactives such as omega-3 and omega-6 polyunsaturated fatty acids and plant-derived antioxidants as means of addressing skin health issues.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22521864
[PubMed - indexed for MEDLINE]
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