Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2012 Jul;23(7):319-25. doi: 10.1016/j.tem.2012.03.004. Epub 2012 Apr 18.

Circadian autophagy rhythm: a link between clock and metabolism?

Author information

  • 1Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

Abstract

Nutrient and energy metabolism in mammals exhibits a strong diurnal rhythm that aligns with the body clock. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. Recent work has demonstrated that autophagy is rhythmically activated in a clock-dependent manner. Because autophagy is a conserved biological process that contributes to nutrient and cellular homeostasis, its cyclic induction may provide a novel link between clock and metabolism. This review discusses the mechanisms underlying circadian autophagy regulation, the role of rhythmic autophagy in nutrient and energy metabolism, and its implications in physiology and metabolic disease.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22520961
[PubMed - indexed for MEDLINE]
PMCID:
PMC3389582
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk