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Am J Obstet Gynecol. 2012 Aug;207(2):107.e1-8. doi: 10.1016/j.ajog.2012.03.030. Epub 2012 Mar 30.

Risk factors for abnormal anal cytology over time in HIV-infected women.

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  • 1Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, MA, USA.

Abstract

OBJECTIVE:

The objective of the study was to assess the incidence of, and risk factors for, abnormal anal cytology and anal intraepithelial neoplasia (AIN) 2-3 in human immunodeficiency virus (HIV)-infected women.

STUDY DESIGN:

This prospective study assessed 100 HIV-infected women with anal and cervical specimens for cytology and high-risk human papillomavirus (HPV) testing over 3 semiannual visits.

RESULTS:

Thirty-three women were diagnosed with an anal cytologic abnormality at least once. Anal cytology abnormality was associated with current CD4 count less than 200 cells/mm(3), anal HPV infection, and a history of other sexually transmitted infections (STIs). Twelve subjects were diagnosed with AIN2-3: 4 after AIN1 diagnosis and 4 after 1 or more negative anal cytology. AIN2-3 trended toward an association with history of cervical cytologic abnormality and history of STI.

CONCLUSION:

Repeated annual anal cytology screening for HIV-infected women, particularly for those with increased immunosuppression, anal and/or cervical HPV, a history of other STIs, or abnormal cervical cytology, will increase the likelihood of detecting AIN2-3.

Copyright © 2012 Mosby, Inc. All rights reserved.

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PMID:
22520651
[PubMed - indexed for MEDLINE]
PMCID:
PMC3408557
Free PMC Article

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