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Nephrol Ther. 2012 Jul;8(4):199-205. doi: 10.1016/j.nephro.2012.03.002. Epub 2012 Apr 18.

[Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?].

[Article in French]

Author information

  • 1Service de Néphrologie-Dialyse-Transplantation, Université de Liège, CHU Sart-Tilman, 4000 Liège, Belgique. pierre_delanaye@yahoo.fr


Measuring or estimating glomerular filtration rate (GFR) is still considered as the best way to apprehend global renal function. In 2009, the new Chronic Kidney Disease Epidemiology (CKD-EPI) equation has been proposed as a better estimator of GFR than the Modification of Diet in Renal Disease (MDRD) study equation. This new equation is supposed to underestimate GFR to a lesser degree in higher GFR levels. In this review, we will present and deeply discuss the performances of this equation. Based on articles published between 2009 and 2012, this review will underline advantages, notably the better knowledge of chronic kidney disease prevalence, but also limitations of this new equation, especially in some specific populations. We eventually insist on the fact that all these equations are estimations and nephrologists should remain cautious in their interpretation.

Copyright © 2012 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

[PubMed - indexed for MEDLINE]
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