Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Org Lett. 2012 May 4;14(9):2402-5. doi: 10.1021/ol300831t. Epub 2012 Apr 20.

Total synthesis of mycocyclosin.

Author information

  • 1School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.

Abstract

The first total synthesis of mycocyclosin, a diketopiperazine natural product isolated from M. tuberculosis, is described. While direct oxidative coupling of tyrosine phenolic groups was unsuccessful, construction of the highly strained bicyclic framework was successfully accomplished through an intramolecular Miyaura-Suzuki cross-coupling to generate the biaryl linkage.

PMID:
22519727
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk