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Nat Rev Immunol. 2012 Apr 20;12(5):325-38. doi: 10.1038/nri3198.

Regulation and function of mTOR signalling in T cell fate decisions.

Author information

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. hongbo.chi@stjude.org

Abstract

The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR signalling to integrate immune signals and metabolic cues for their proper maintenance and activation. Under steady-state conditions, mTOR is actively controlled by multiple inhibitory mechanisms, and this enforces normal T cell homeostasis. Antigen recognition by naive CD4(+) and CD8(+) T cells triggers mTOR activation, which in turn programmes the differentiation of these cells into functionally distinct lineages. This Review focuses on the signalling mechanisms of mTOR in T cell homeostatic and functional fates, and discusses the therapeutic implications of targeting mTOR in T cells.

PMID:
22517423
[PubMed - indexed for MEDLINE]
PMCID:
PMC3417069
Free PMC Article
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