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FEMS Immunol Med Microbiol. 2012 Aug;65(3):505-9. doi: 10.1111/j.1574-695X.2012.00974.x. Epub 2012 May 21.

Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model.

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  • 1Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD, USA.


The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y . pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.

© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

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