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Prostate. 2012 Dec 1;72(16):1746-56. doi: 10.1002/pros.22527. Epub 2012 Apr 18.

Long-term recovery of irradiated prostate cancer increases cancer stem cells.

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  • 1Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.

Abstract

BACKGROUND:

Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies, but their role in PC has not yet been investigated.

METHODS:

We compared the relative radiosensitivity of isolated CSCs to the total population of their corresponding cell lines, and examined the relative numbers of CSCs in irradiated cell lines following long-term recovery and in recurrent human PC.

RESULTS:

Here, we show that while irradiation does not immediately favor increased survival of CSCs, irradiated PC cell lines showed an increase in CSC properties with long-term recovery. These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth.

CONCLUSIONS:

The combination of radiotherapy with a CSC-targeted therapeutic strategy may prevent tumor recurrence.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
22513891
[PubMed - indexed for MEDLINE]
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