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Am J Clin Nutr. 2012 Jun;95(6):1477-86. doi: 10.3945/ajcn.111.026955. Epub 2012 Apr 18.

Obesity susceptibility loci and dietary intake in the Look AHEAD Trial.

Collaborators (297)

Brancati FL, Honas J, Cheskin LJ, Clark JM, Stewart K, Rubin R, Charleston J, Horak K, Bray A, Rau K, Strate A, Armand B, Greenway FL, Ryan DH, Williamson D, Bachand A, Begnaud M, Berhard B, Caderette E, Cerniauskas B, Creel D, Crow D, Guay H, Kora N, LaFleur K, Landry K, Lingle M, Perault J, Shipp M, Smith M, Tucker E, Lewis CE, Thomas S, Safford M, DiLillo V, Bragg C, Dobelstein A, Gilbert S, Glasser S, Hannum S, Hubbell A, Jones J, Lee D, Luketic R, Marshall K, Oden LC, Raines J, Roche C, Truman J, Webb N, Wrenn A, Nathan DM, Turgeon H, Schumann K, Cagliero E, Delahanty L, Hayward K, Anderson E, Bissett L, Ginsburg R, Goldman V, Harlan V, McKitrick C, McNamara A, Michel T, Poulos A, Steiner B, Tosch J, Horton ES, Jackson SD, Hamdy O, Caballero E, Bain S, Bovaird E, Goebel-Fabbri A, Lambert L, Ledbury S, Malloy M, Ovalle K, Blackburn G, Mantzoros C, Day K, McNamara A, Hill JO, Miller M, Phillipp J, Schwartz R, Van Dorsten B, Regensteiner J, Benchekroun S, Coelho L, Cohrs P, Daeninck E, Fields A, Green S, Hamilton A, Hamilton J, Leshchinskiy E, McDermott M, Munkwitz L, Rome L, Wallace K, Worley T, Foreyt JP, Reeves RS, Pownall H, Balasubramanyam A, Jones P, Burrington M, Chen CH, Clark A, Gee M, Griggs S, Hamilton M, Holler V, Joseph J, Pace P, Palencia J, Satterwhite O, Schmidt J, Volding D, White C, Johnson KC, Gresham C, Connelly S, Brewer A, Coday M, Jones L, Lichtermann L, Vosburg S, Taylor JL, Kitabchi AE, Lambeth H, Clark D, Crisler A, Cunningham G, Green D, Force D, Kores R, Rosenthal R, Smith E, Sun M, Soberman J, Jeffery RW, Thorson C, Bantle JP, Redmon JB, Crow RS, Crow S, Raatz SK, Brelje K, Campbell C, Carls J, Carmean-Mihm T, Finch E, Fox A, Hoelscher E, James LD, Maddy VA, Ockenden T, Rice BI, Tucker AD, Voeller MS, Walcheck C, Pi-Sunyer X, Patricio J, Heshka S, Pal C, Allen L, Hirsch D, Holowaty MA, Wadden TA, Maschak-Carey BJ, Schwartz S, Foster GD, Berkowitz RI, Glick H, Kumanyika SK, Brock J, Chomentowski H, Clark V, Crerand C, Davenport R, Diamond A, Fabricatore A, Hesson L, Krauthamer-Ewing S, Kuehnel R, Lipschutz P, Mullen M, Womble L, Iqbal N, Kelley DE, Wesche-Thobaben J, Kuller L, Kriska A, Bonk J, Danchenko R, Edmundowicz D, Klem ML, Yamamoto ME, Elnyczky B, Grove GA, Harper P, Krulia J, Mancino J, Mathews A, Murray TY, Ritchea JR, Rush J, Vujevich K, Wolf D, Wing RR, Bright R, Pera V, Jakicic J, Tate D, Gorin A, Gallagher K, Bach A, Bancroft B, Bertorelli A, Carey R, Charron T, Chenot H, Chula-Maguire K, Coward P, Cronkite L, Currin J, Daly M, Egan C, Ferguson E, Foss L, Gauvin J, Kieffer D, Lessard L, Maier D, Massaro JP, Monk T, Nicholson R, Patterson E, Phelan S, Raynor H, Raynor D, Robinson N, Robles D, Tavares J, Haffner SM, Montez MG, Lorenzo C, Kahn S, Montgomery B, Knopp R, Lipkin E, Maciejewski ML, Trence D, Barrett T, Bartell J, Greenberg D, Murillo A, Richmond BA, Thomas A, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D, Reynolds PS, Ribisl P, Vitolins M, Booth M, Dotson KM, Hodges A, Williams CC, Barnes JM, Feeney PA, Griffin J, Harvin L, Herman W, Hogan P, Jaramillo S, King M, Lane K, Neiberg R, Ruggiero A, Speas C, Walkup MP, Wall K, Ward M, West DS, Windham T, Marcovina SM, Strylewicz G.

Abstract

BACKGROUND:

Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear.

OBJECTIVE:

The objective was to determine the association between obesity susceptibility loci and dietary intake.

DESIGN:

The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site.

RESULTS:

Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004). Risk variants within BDNF were significantly associated with more servings from the dairy product and the meat, eggs, nuts, and beans food groups (P ≤ 0.004). The risk allele at SH2B1 rs4788099 was significantly associated with more servings of dairy products (P = 0.001), whereas the risk allele at TNNI3K rs1514176 was significantly associated with a lower percentage of energy from protein (P = 0.002).

CONCLUSION:

These findings suggest that obesity risk loci may affect the pattern and content of food consumption among overweight or obese individuals with type 2 diabetes. The Look AHEAD Genetic Ancillary Study was registered at clinicaltrials.gov as NCT01270763 and the Look AHEAD study as NCT00017953.

PMID:
22513296
[PubMed - indexed for MEDLINE]
PMCID:
PMC3349457
Free PMC Article

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