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    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9411-5.

    Expression and chromosomal localization of a lymphocyte K+ channel gene.

    Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG.

    Department of Physiology and Biophysics, University of California, Irvine 92715.

    We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively.

    PMID: 2251283 [PubMed - indexed for MEDLINE]

    PMCID: 55175

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