Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Can J Physiol Pharmacol. 2012 Jun;90(6):697-703. doi: 10.1139/y2012-049. Epub 2012 Apr 17.

On the disruption of biochemical and biological assays by chemicals leaching from disposable laboratory plasticware.

Author information

  • 1Department of Pharmacology, Faculty of Medicine and Dentistry, 9-70 Medical Sciences Building, University of Alberta, Edmonton, AB T6G 2H7, Canada.

Abstract

Plastic consumables, used universally in bioscience laboratories, are presumed inert with respect to bioassay outcomes. However, it is clear that many pipette tips, microfuge tubes, and other plastic disposables leach bioactive compounds into assay solutions, profoundly affecting data and experimental interpretation. In this paper we discuss the nature and sources of leachates and review several examples of compromised bioassay data that speak to the probable widespread nature of this largely unrecognised source of error. Strategies for minimizing leachate interferences are discussed.

PMID:
22509735
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon
    Loading ...
    Write to the Help Desk