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Genes Dev. 2012 Apr 15;26(8):756-84. doi: 10.1101/gad.187922.112.

Emerging insights into the molecular and cellular basis of glioblastoma.

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  • 1Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Abstract

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.

PMID:
22508724
[PubMed - indexed for MEDLINE]
PMCID:
PMC3337451
Free PMC Article
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