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Ann Rehabil Med. 2012 Feb;36(1):159-62. doi: 10.5535/arm.2012.36.1.159. Epub 2012 Feb 29.

Cefepime neurotoxicity in patients with renal insufficiency.

Author information

  • 1Department of Rehabilitation Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, Korea.

Abstract

Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients with renal impairment who developed neurotoxicity including lethal outcome after treatment with cefepime.

KEYWORDS:

Cefepime; Neurotoxicity; Renal failure

PMID:
22506251
[PubMed]
PMCID:
PMC3309312
Free PMC Article

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