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Angew Chem Int Ed Engl. 2012 May 14;51(20):4860-3. doi: 10.1002/anie.201200596. Epub 2012 Apr 13.

Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins.

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  • 1Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
22505324
[PubMed - indexed for MEDLINE]
PMCID:
PMC3517101
Free PMC Article

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