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Cell Mol Immunol. 2012 May;9(3):237-44. doi: 10.1038/cmi.2012.7. Epub 2012 Apr 16.

HIV-1 immunopathogenesis in humanized mouse models.

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  • 1Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. liguozhang@ibp.ac.cn

Abstract

In recent years, the technology of constructing chimeric mice with humanized immune systems has markedly improved. Multiple lineages of human immune cells develop in immunodeficient mice that have been transplanted with human hematopoietic stem cells. More importantly, these mice mount functional humoral and cellular immune responses upon immunization or microbial infection. Human immunodeficiency virus type I (HIV-1) can establish an infection in humanized mice, resulting in CD4(+) T-cell depletion and an accompanying nonspecific immune activation, which mimics the immunopathology in HIV-1-infected human patients. This makes humanized mice an optimal model for studying the mechanisms of HIV-1 immunopathogenesis and for developing novel immune-based therapies.

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