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Immunol Rev. 2012 May;247(1):36-51. doi: 10.1111/j.1600-065X.2012.01114.x.

S1PR2 links germinal center confinement and growth regulation.

Author information

  • 1Department of Microbiology and Immunology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0414, USA.

Abstract

Germinal centers (GCs) are sites of rapid B-cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B-cell selection events are currently under intense scrutiny. In recent study, we identified a role for a migration inhibitory receptor, S1PR2, in promoting GC B-cell confinement to GCs. S1PR2 also dampens Akt activation and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth control in chronically stimulated mucosal GCs. Herein, we detail present understanding of S1PR2 and S1P biology as it pertains to GC B cells and place this information in the context of a current model of GC function.

© 2012 John Wiley & Sons A/S.

PMID:
22500830
[PubMed - indexed for MEDLINE]
PMCID:
PMC3335345
Free PMC Article

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