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Curr Biol. 2012 Apr 10;22(7):R233-5. doi: 10.1016/j.cub.2012.02.059.

Chromosomal Instability: Mad2 beyond the spindle checkpoint.

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  • 1Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.


What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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