Axon degeneration: where the Wlds things are

Curr Biol. 2012 Apr 10;22(7):R221-3. doi: 10.1016/j.cub.2012.02.056.

Abstract

Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axons / pathology*
  • Calcium / metabolism*
  • Disease Models, Animal*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster*
  • Humans
  • Mitochondria / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Nicotinamide-Nucleotide Adenylyltransferase / metabolism*
  • Wallerian Degeneration / genetics*
  • Wallerian Degeneration / metabolism*

Substances

  • Drosophila Proteins
  • Nerve Tissue Proteins
  • Wld protein, mouse
  • Nicotinamide-Nucleotide Adenylyltransferase
  • Calcium