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Int J Surg Pathol. 2012 Dec;20(6):618-22. doi: 10.1177/1066896912436554. Epub 2012 Apr 11.

Giant cell tumor of uterus resembling osseous giant cell tumor: case report and review of literature.

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  • 1Hofstra North Shore-LIJ School of Medicine, Lake Success, NY 11042, USA.


Osteoclast-like giant cells (OLGCs) are multinucleated cells of histiocytic lineage and have been identified in a wide array of neoplasms. In the uterus, they have most frequently been reported in association with leiomyosarcomas. This article describes a case of an osteoclast-like giant cell-rich uterine tumor that was essentially indistinguishable at the morphologic and immunophenotypic levels, from typical giant cell tumor of bone. This is the first example of such a case that has been reported in the uterus to the authors' knowledge.

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