Display Settings:

Format

Send to:

Choose Destination
Drug Discov Today. 2012 Mar;17(5-6):261-8.

Stratified medicine for cancer therapy.

Author information

  • 1Cancer Research UK, London, UK.

Abstract

As knowledge of the biological processes underlying malignant transformation becomes increasingly sophisticated, apparently similar diseases can be redefined according to the critical disrupted biological pathways and networks. The key genetic changes in most cancers can be mapped to one of a relatively few pathways, making it possible to classify tumours by their abnormal pathways and to identify potentially treatable--'druggable'--targets within these. The aim of the stratified approach to cancer therapy is to improve the effectiveness, tolerability and affordability of novel therapeutic agents.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22493785
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk