Format

Send to:

Choose Destination
See comment in PubMed Commons below
Front Physiol. 2012 Apr 5;3:73. doi: 10.3389/fphys.2012.00073. eCollection 2012.

Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals.

Author information

  • 1Department of Biology, University Roma Tre Roma, Italy.

Abstract

Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the nuclear receptor super-family. As members of the ligand-regulated transcription factor family, classically, the actions of ERs in the brain were thought to mediate only the E2 long-term transcriptional effects. However, a growing body of evidence highlighted rapid, membrane initiated E2 effects in the brain that are independent of ER transcriptional activities and are involved in E2-induced neuroprotection. The aim of this review is to focus on the rapid effects of E2 in the brain highlighting the specific role of the signaling pathway(s) of the ERβ subtype in the neuroprotective actions of E2.

KEYWORDS:

17β-estradiol; estrogen receptor α; estrogen receptor β; membrane initiated signals; neuroprotective effects

PMID:
22493583
[PubMed]
PMCID:
PMC3319910
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk