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Anticancer Res. 2012 Apr;32(4):1443-8.

Histopathological classification of pseudomyxoma peritonei and the prognostic importance of PINCH protein.

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  • 1Department of Surgical Sciences, Section of Surgery, Uppsala University, Uppsala, Sweden.

Abstract

AIM:

The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.

MATERIALS AND METHODS:

Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.

RESULTS:

The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).

CONCLUSION:

The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.

PMID:
22493383
[PubMed - indexed for MEDLINE]
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