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J Gen Virol. 2012 Jul;93(Pt 7):1530-6. doi: 10.1099/vir.0.040634-0. Epub 2012 Apr 4.

Novel microRNAs encoded by duck enteritis virus.

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  • 1Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK.

Abstract

Duck enteritis virus (DEV) is an important herpesvirus pathogen associated with acute, highly contagious lethal disease in waterfowls. Using a deep sequencing approach on RNA from infected chicken embryo fibroblast cultures, we identified several novel DEV-encoded micro (mi)RNAs. Unlike most mardivirus-encoded miRNAs, DEV-encoded miRNAs mapped mostly to the unique long region of the genome. The precursors of DEV miR-D18 and miR-D19 overlapped with each other, suggesting similarities to miRNA-offset RNAs, although only the DEV-miR-D18-3p was functional in reporter assays. Identification of these novel miRNAs will add to the growing list of virus-encoded miRNAs enabling the exploration of their roles in pathogenesis.

PMID:
22492913
[PubMed - indexed for MEDLINE]
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