Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pediatrics. 2012 May;129(5):e1192-8. doi: 10.1542/peds.2011-2601. Epub 2012 Apr 9.

Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease.

Author information

  • 1Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Abstract

OBJECTIVES:

To examine the combined effect of alcohol and folate intake during adolescence on the risk of proliferative benign breast disease (BBD).

METHODS:

We used data from 29‚ÄČ117 women in the Nurses' Health Study II who completed both adolescent alcohol consumption questions in 1989 and an adolescent diet questionnaire in 1998. A total of 659 women with proliferative BBD diagnosed between 1991 and 2001 were confirmed by central pathology review. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CIs), adjusted for established risk factors of breast cancer.

RESULTS:

Adolescent alcohol consumption was dose-dependently associated with an increased risk of proliferative BBD (hazard ratio = 1.15 per 10 g/day consumption; 95% CI, 1.03-1.28). There was no significant association between adolescent folate intake and the risk of proliferative BBD. Stratified analyses showed that each 10-g/day alcohol intake during adolescence was associated with a 21% (95% CI, 1.01-1.45) increase in the risk of proliferative BBD among women with low folate intake during adolescence, which was not significantly different from the alcohol-associated risk among women with moderate and high folate intake during adolescence (P for interaction = 0.18).

CONCLUSIONS:

Adolescent alcohol consumption is associated with increased risk of proliferative BBD, which may not be reduced by increased folate intake during adolescence.

PMID:
22492774
[PubMed - indexed for MEDLINE]
PMCID:
PMC3866773
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk