Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurology. 2012 Apr 10;78(15):1138-45. doi: 10.1212/WNL.0b013e31824f7fc4. Epub 2012 Apr 4.

Habitual intake of dietary flavonoids and risk of Parkinson disease.

Author information

  • 1Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School,Boston, MA, USA. xiang.gao@channing.harvard.edu

Abstract

OBJECTIVE:

To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD).

METHODS:

In the current analysis, we included 49,281 men in the Health Professional Follow-up Study and 80,336 women from the Nurses' Health Study. Five major sources of flavonoid-rich foods (tea, berry fruits, apples, red wine, and orange/orange juice) were also examined. Flavonoid intake was assessed using an updated food composition database and a validated food frequency questionnaire.

RESULTS:

We identified 805 participants (438 men and 367 women) who developed PD during 20-22 years of follow-up. In men, after adjusting for multiple confounders, participants in the highest quintile of total flavonoids had a 40%lower PD risk than those in the lowest quintile (hazard ratio [HR] = 0.60; 95% confidence interval 0.43, 0.83; p trend = 0.001). No significant relationship was observed in women (p trend = 0.62) or in pooled analyses (p trend = 0.23). In the pooled analyses for the subclasses, intakes of anthocyanins and a rich dietary source, berries, were significantly associated with a lower PD risk (HR comparing 2 extreme intake quintiles were 0.76 for anthocyanins and 0.77 for berries, respectively; p trend < 0.02 for both).

CONCLUSIONS:

Our findings suggest that intake of some flavonoids may reduce PD risk, particularly in men, but a protective effect of other constituents of plant foods cannot be excluded.

Comment in

PMID:
22491871
[PubMed - indexed for MEDLINE]
PMCID:
PMC3320056
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk