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ScientificWorldJournal. 2012;2012:975971. doi: 10.1100/2012/975971. Epub 2012 Mar 12.

Magnetic resonance image-guided biopsies with a high detection rate of prostate cancer.

Author information

  • 1Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany. dirk.engehausen@uk-erlangen.de

Abstract

AIM:

To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies.

PATIENTS AND METHODS:

Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time imaging control in supine position.

RESULTS:

Adenocarcinoma of the prostate was detected in 39 of 96 patients. For individual core biopsies, MRI yielded a sensitivity of 93.0% and a specificity of 94.4%. When stratifying patients according to the free-to-total prostate-specific antigen (PSA) ratio, the prostate cancer discovery rate was significantly higher in the group with ratios less than 0.15 (57.1%).

CONCLUSION:

MRI-guided biopsy of the prostate is a diagnostic option for patients with suspected prostate cancer and a history of repeatedly negative transrectal ultrasound-guided biopsies. Combined with the free-to-total PSA ratio, it is a highly effective method for detecting prostate cancer.

PMID:
22489209
[PubMed - indexed for MEDLINE]
PMCID:
PMC3317570
Free PMC Article
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