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Pediatr Pulmonol. 2013 Jan;48(1):102-3. doi: 10.1002/ppul.22563. Epub 2012 Apr 9.

Suicidal ideation and thought disorder associated with the formoterol component of combined asthma medication.

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  • 1University of Colorado School of Pharmacy, Denver, CO 80206, USA.


Combination inhaled asthma medications containing corticosteroids and long-acting beta-adrenergic (LABA) agents are generally well tolerated, although a small minority of children receiving them may develop side-effects. Herein is reported a case of a 9-year-old boy who developed insomnia, pressured speech, agitation, and suicidal ideation within the 1st month after initiating formoterol + budesonide. He had not received oral glucocorticoids for >90 days. All symptoms resolved within 48 hr upon discontinuing formoterol while continuing budesonide. To our knowledge, this is the first report of childhood suicidal ideation strongly associated with use of a combination inhaled corticosteroid/LABA.

Copyright © 2012 Wiley Periodicals, Inc.

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