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Onkologie. 2012;35(4):196-9. doi: 10.1159/000337405. Epub 2012 Mar 15.

Penile metastasis from primary bladder cancer: a study of 8 cases and review of the literature.

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  • 1Department of Urology, Fudan University Shanghai Cancer Center, China.



Penile metastases from primary bladder cancer are extremely rare.


The medical records of 8 patients who presented with metastatic penile carcinoma originating from bladder between 2002 and 2010 were analyzed. The main complaint was a painless nodule (6 cases), priapism (1 case), and penile pain (1 case). All of the penile metastases were metachronous. The interval between primary cancer and penile metastases ranged from 1 to 100 months (mean 26.4 months). Total penectomy combined with systemic chemotherapy was the treatment of choice in 4 cases. 1 patient only accepted external beam radiotherapy, and 3 patients only accepted chemotherapy due to disseminated disease. The time interval between penile metastases and death ranged from 4 to 23 months (mean 11.4 months).


Penile metastases secondary to primary bladder cancer are rare and represent a challenging problem. The common mode of spread to the penis is by retrograde venous route. The overall outcome is very poor, and most patients will die within 1 year despite systemic chemotherapy and supportive care. Radical ablative surgery is justified only for symptomatic relief.

Copyright © 2012 S. Karger AG, Basel.

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