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Carbohydr Res. 2012 Jul 15;356:37-43. doi: 10.1016/j.carres.2012.03.013. Epub 2012 Mar 23.

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.

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  • 1Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043, Japan. yukarif@chem.sci.osaka-u.ac.jp

Abstract

Helicobacter pylori, a Gram-negative bacterium, causes gastroduodenal inflammatory diseases such as chronic gastritis and peptic ulcers, and is also a risk factor for gastric carcinogenesis. In this article, we review recent developments and findings in the chemical synthesis and immunomodulatory activities of H. pylori lipid A and 3-deoxy-D-manno-2-octulosonic acid (Kdo)-lipid A, to clarify the structural basis for the inflammatory response to H. pylori LPS. The synthetic methods include a new divergent synthetic approach with a widely applicable key intermediate for other types of lipid A structures, as well as a selective α-glycosylation reaction between Kdo and lipid A. Cytokine induction assays of the chemically synthesized lipid A structures showed selective cytokine induction depending on the patterns of acyl groups and phosphate groups. The results of cytokine induction assay suggested that H. pylori LPS can modulate the immune response during infection, and also plays a role in chronic inflammatory responses.

Copyright © 2012. Published by Elsevier Ltd.

[PubMed - indexed for MEDLINE]
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