Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Kidney Dis. 2012 Jul;60(1):47-53. doi: 10.1053/j.ajkd.2012.01.023. Epub 2012 Apr 6.

A varying patient safety profile between black and nonblack adults with decreased estimated GFR.

Author information

  • 1Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA. cdiamantidis@medicine.umaryland.edu

Abstract

BACKGROUND:

Chronic kidney disease is a high-risk condition for a variety of adverse safety events, yet little is known about differential rates of safety events across racial groups with decreased kidney function. We sought to examine the incidence of an array of disease-specific adverse safety events in black versus nonblack patients with decreased estimated glomerular filtration rate (eGFR).

STUDY DESIGN:

Retrospective observational study of a national US Veterans Affairs cohort.

SETTINGS & PARTICIPANTS:

Veterans with eGFR <60 mL/min/1.73 m(2) and one or more hospitalization during federal fiscal year 2005 (n = 70,154).

PREDICTOR:

Self-reported race/ethnicity dichotomized as black or nonblack.

OUTCOMES:

Hospital discharge coding for Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs), laboratory records for detection of hyperkalemia and hypoglycemia, and pharmacy records to determine dosing of 4 selected medications.

MEASUREMENTS:

Relationship between race and disease-specific patient safety events.

RESULTS:

Black veterans were more likely than nonblack veterans to experience one type of safety event (33% vs 32%, respectively) and multiple types of safety events (32% vs 23%, respectively; both P < 0.001). After adjustment, black veterans were 11% and 36% more likely to have at least one episode of hyperkalemia and hypoglycemia, respectively, than nonblack veterans, but were 14% less likely to experience a medication error (all P < 0.001). There was no association between the occurrence of AHRQ PSIs and race after adjustment.

LIMITATIONS:

Use of administrative data has a risk of imprecision in coding; Veterans Affairs cohort may limit generalizability.

CONCLUSIONS:

Black veterans with decreased eGFR are more likely to experience a broad array of safety events than nonblacks with decreased eGFR, with a preponderance of metabolic disturbances rather than medication errors or AHRQ PSIs. The differential safety phenotype in blacks versus nonblacks may have implications for preventive strategies to improve patient safety in an integrated health care system.

Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk