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Prog Mol Biol Transl Sci. 2012;107:101-24. doi: 10.1016/B978-0-12-385883-2.00012-6.

Alzheimer's disease and the amyloid β-protein.

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  • 1Laboratory for Neurodegenerative Research, Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts, USA.

Abstract

Alzheimer's disease is a devastating disorder that is estimated to affect more than 25 million people worldwide and for which there are no preventive, disease-modifying, or curative therapies. Substantial evidence indicates that the amyloid β-protein (Aβ) is a seminal factor in disease causation and may be a tractable therapeutic target. The ability of Aβ to self-associate to form oligomeric assemblies appears to underlie the early toxic events that lead to memory impairment and subsequent neurodegeneration. We review here research on Aβ folding, self-assembly, and toxicity, highlighting areas critical for the development of efficacious Aβ-directed therapeutics.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22482449
[PubMed - indexed for MEDLINE]
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