Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Cell Biol. 2012;2012:142634. doi: 10.1155/2012/142634. Epub 2012 Feb 20.

The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective.

Author information

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

Abstract

From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (Atg) components that function as the protein machinery that drives the dynamic membrane events of autophagy. It may be difficult, especially for scientists new to this area of research, to appreciate that the field of autophagy long existed as a "backwater" topic that attracted little interest or attention. Paralleling the development of the autophagy field was the identification and analysis of the cytoplasm-to-vacuole targeting (Cvt) pathway, the only characterized biosynthetic route that utilizes the Atg proteins. Here, we relate some of the initial history, including some never-before-revealed facts, of the analysis of the Cvt pathway and the convergence of those studies with autophagy.

PMID:
22481942
[PubMed]
PMCID:
PMC3296166
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk