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Schizophr Res. 2012 Jul;138(2-3):157-63. doi: 10.1016/j.schres.2012.03.019. Epub 2012 Apr 3.

Hippocampal novelty activations in schizophrenia: disease and medication effects.

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  • 1Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States. Carol.tamminga@utsouthwestern.edu

Abstract

We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22480957
[PubMed - indexed for MEDLINE]
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