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Nat Rev Cancer. 2012 Apr 5;12(5):363-8. doi: 10.1038/nrc3235.

Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.

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  • 1Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.


The past decade has seen dramatic technological advances in the field of optical coherence tomography (OCT) imaging. These advances have driven commercialization and clinical adoption in ophthalmology, cardiology and gastrointestinal cancer screening. Recently, an array of OCT-based imaging tools that have been developed for preclinical intravital cancer imaging applications has yielded exciting new capabilities to probe and to monitor cancer progression and response in vivo. Here, we review these results, forecast the future of OCT for preclinical cancer imaging and discuss its exciting potential to translate to the clinic as a tool for monitoring cancer therapy.

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