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Autoimmune Dis. 2012;2012:645967. doi: 10.1155/2012/645967. Epub 2012 Mar 5.

Neurological Disorders in Primary Sjögren's Syndrome.

Author information

  • 1EA Immunologie et Pathologie, Université de Bretagne Occidentale et Centre Hospitalier Universitaire de Brest, BP 824, F2969 Brest, France.

Abstract

Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. This paper endeavors to review the main clinical neurological manifestations in Sjögren syndrome, the physiopathology, and their therapeutic response.

PMID:
22474573
[PubMed]
PMCID:
PMC3303537
Free PMC Article

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