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Am J Surg Pathol. 2012 Jun;36(6):889-94. doi: 10.1097/PAS.0b013e31824fff50.

Is there a spectrum of cytologic atypia in type a thymomas analogous to that seen in type B thymomas? A pilot study of 13 cases.

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  • 1Department of Histopathology, The Christie Hospital, NHS Foundation Trust, Wilmslow Road, Manchester, UK.


Thirteen cases of type A thymoma are reported showing the characteristic architectural attributes of this tumor type (World Health Organization), such as lobulation, perivascular spaces, gland-like formations, and cystic changes, but also displaying atypical features, as defined by increased mitotic activity, mild to moderate nuclear atypia, and/or scattered small foci of necrosis. The tumors were similar to type B3 thymomas in many respects, except for the fact that the tumor cells were spindled instead of round/polygonal. The existence of these cases suggests the desirability of an expansion of the type A thymoma category, analogous to that currently used for type B tumors. The various nomenclature options that could be used to name these tumors have been discussed.

[PubMed - indexed for MEDLINE]
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